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1 st order exponential nonlinear curve fitting equation  (OriginLab corp)

 
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    OriginLab corp 1 st order exponential nonlinear curve fitting equation
    (A) Representative current traces from a cell expressing Kv2.1 channel before (HR; black trace) and during treatment with σ1-R receptor agonist PRE084 (10 μM, red trace). Inset voltage pulse to 50 mV from a holding potential of -60 mV. (B) Representative Kv2.1 channel current traces from a cell treated with σ1-R antagonist BD1047 (50 μM, red trace) compared to total current (black trace). (C) Comparison of Kv2.1 current traces before (HR, black trace) and during treatment with σ1-R antagonist NE100 (50 μM, red trace). (D) Time course of current amplitude at +60 mV. Recordings during Pre84 treatment is represented as red filled circles. (E) Filled circles (red) showing current amplitude time course during treatment of Kv2.1 expressing cells with BD1047. (F) Kv2.1 outward current amplitude as in D in presence of NE100 (50 μM, red filled circles). Both in E and F the solid line represents single <t>exponential</t> curve fit. (G) Average Kv2.1 whole-cell normalized current-voltage plot obtained in control solution (black squares) and during application of Pre084. (H) Comparison of average normalized current-voltage curve in presence of control bath solution and BD1047. (I) Average normalized current-voltage curve determined in control solution (black squares) and NE100 (red circles). (J) The G-V relationships of the control (solid black square), and in presence of BD1047 (blue triangle) or NE100 (red circle) are illustrated. (K) Normalized G-V curves as in J were fitted with the Boltzmann function. Data points in G-K are mean ± SEM (n=5). * P < 0.05 compared to control.
    1 St Order Exponential Nonlinear Curve Fitting Equation, supplied by OriginLab corp, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/1 st order exponential nonlinear curve fitting equation/product/OriginLab corp
    Average 90 stars, based on 1 article reviews
    1 st order exponential nonlinear curve fitting equation - by Bioz Stars, 2026-03
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    1) Product Images from "Potential independent action of sigma receptor ligands through inhibition of the Kv2.1 channel"

    Article Title: Potential independent action of sigma receptor ligands through inhibition of the Kv2.1 channel

    Journal: Oncotarget

    doi: 10.18632/oncotarget.19581

    (A) Representative current traces from a cell expressing Kv2.1 channel before (HR; black trace) and during treatment with σ1-R receptor agonist PRE084 (10 μM, red trace). Inset voltage pulse to 50 mV from a holding potential of -60 mV. (B) Representative Kv2.1 channel current traces from a cell treated with σ1-R antagonist BD1047 (50 μM, red trace) compared to total current (black trace). (C) Comparison of Kv2.1 current traces before (HR, black trace) and during treatment with σ1-R antagonist NE100 (50 μM, red trace). (D) Time course of current amplitude at +60 mV. Recordings during Pre84 treatment is represented as red filled circles. (E) Filled circles (red) showing current amplitude time course during treatment of Kv2.1 expressing cells with BD1047. (F) Kv2.1 outward current amplitude as in D in presence of NE100 (50 μM, red filled circles). Both in E and F the solid line represents single exponential curve fit. (G) Average Kv2.1 whole-cell normalized current-voltage plot obtained in control solution (black squares) and during application of Pre084. (H) Comparison of average normalized current-voltage curve in presence of control bath solution and BD1047. (I) Average normalized current-voltage curve determined in control solution (black squares) and NE100 (red circles). (J) The G-V relationships of the control (solid black square), and in presence of BD1047 (blue triangle) or NE100 (red circle) are illustrated. (K) Normalized G-V curves as in J were fitted with the Boltzmann function. Data points in G-K are mean ± SEM (n=5). * P < 0.05 compared to control.
    Figure Legend Snippet: (A) Representative current traces from a cell expressing Kv2.1 channel before (HR; black trace) and during treatment with σ1-R receptor agonist PRE084 (10 μM, red trace). Inset voltage pulse to 50 mV from a holding potential of -60 mV. (B) Representative Kv2.1 channel current traces from a cell treated with σ1-R antagonist BD1047 (50 μM, red trace) compared to total current (black trace). (C) Comparison of Kv2.1 current traces before (HR, black trace) and during treatment with σ1-R antagonist NE100 (50 μM, red trace). (D) Time course of current amplitude at +60 mV. Recordings during Pre84 treatment is represented as red filled circles. (E) Filled circles (red) showing current amplitude time course during treatment of Kv2.1 expressing cells with BD1047. (F) Kv2.1 outward current amplitude as in D in presence of NE100 (50 μM, red filled circles). Both in E and F the solid line represents single exponential curve fit. (G) Average Kv2.1 whole-cell normalized current-voltage plot obtained in control solution (black squares) and during application of Pre084. (H) Comparison of average normalized current-voltage curve in presence of control bath solution and BD1047. (I) Average normalized current-voltage curve determined in control solution (black squares) and NE100 (red circles). (J) The G-V relationships of the control (solid black square), and in presence of BD1047 (blue triangle) or NE100 (red circle) are illustrated. (K) Normalized G-V curves as in J were fitted with the Boltzmann function. Data points in G-K are mean ± SEM (n=5). * P < 0.05 compared to control.

    Techniques Used: Expressing, Comparison, Control



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    1 st order exponential nonlinear curve fitting equation  (OriginLab corp)
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    OriginLab corp 1 st order exponential nonlinear curve fitting equation
    (A) Representative current traces from a cell expressing Kv2.1 channel before (HR; black trace) and during treatment with σ1-R receptor agonist PRE084 (10 μM, red trace). Inset voltage pulse to 50 mV from a holding potential of -60 mV. (B) Representative Kv2.1 channel current traces from a cell treated with σ1-R antagonist BD1047 (50 μM, red trace) compared to total current (black trace). (C) Comparison of Kv2.1 current traces before (HR, black trace) and during treatment with σ1-R antagonist NE100 (50 μM, red trace). (D) Time course of current amplitude at +60 mV. Recordings during Pre84 treatment is represented as red filled circles. (E) Filled circles (red) showing current amplitude time course during treatment of Kv2.1 expressing cells with BD1047. (F) Kv2.1 outward current amplitude as in D in presence of NE100 (50 μM, red filled circles). Both in E and F the solid line represents single <t>exponential</t> curve fit. (G) Average Kv2.1 whole-cell normalized current-voltage plot obtained in control solution (black squares) and during application of Pre084. (H) Comparison of average normalized current-voltage curve in presence of control bath solution and BD1047. (I) Average normalized current-voltage curve determined in control solution (black squares) and NE100 (red circles). (J) The G-V relationships of the control (solid black square), and in presence of BD1047 (blue triangle) or NE100 (red circle) are illustrated. (K) Normalized G-V curves as in J were fitted with the Boltzmann function. Data points in G-K are mean ± SEM (n=5). * P < 0.05 compared to control.
    1 St Order Exponential Nonlinear Curve Fitting Equation, supplied by OriginLab corp, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/1 st order exponential nonlinear curve fitting equation/product/OriginLab corp
    Average 90 stars, based on 1 article reviews
    1 st order exponential nonlinear curve fitting equation - by Bioz Stars, 2026-03
    90/100 stars
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    (A) Representative current traces from a cell expressing Kv2.1 channel before (HR; black trace) and during treatment with σ1-R receptor agonist PRE084 (10 μM, red trace). Inset voltage pulse to 50 mV from a holding potential of -60 mV. (B) Representative Kv2.1 channel current traces from a cell treated with σ1-R antagonist BD1047 (50 μM, red trace) compared to total current (black trace). (C) Comparison of Kv2.1 current traces before (HR, black trace) and during treatment with σ1-R antagonist NE100 (50 μM, red trace). (D) Time course of current amplitude at +60 mV. Recordings during Pre84 treatment is represented as red filled circles. (E) Filled circles (red) showing current amplitude time course during treatment of Kv2.1 expressing cells with BD1047. (F) Kv2.1 outward current amplitude as in D in presence of NE100 (50 μM, red filled circles). Both in E and F the solid line represents single exponential curve fit. (G) Average Kv2.1 whole-cell normalized current-voltage plot obtained in control solution (black squares) and during application of Pre084. (H) Comparison of average normalized current-voltage curve in presence of control bath solution and BD1047. (I) Average normalized current-voltage curve determined in control solution (black squares) and NE100 (red circles). (J) The G-V relationships of the control (solid black square), and in presence of BD1047 (blue triangle) or NE100 (red circle) are illustrated. (K) Normalized G-V curves as in J were fitted with the Boltzmann function. Data points in G-K are mean ± SEM (n=5). * P < 0.05 compared to control.

    Journal: Oncotarget

    Article Title: Potential independent action of sigma receptor ligands through inhibition of the Kv2.1 channel

    doi: 10.18632/oncotarget.19581

    Figure Lengend Snippet: (A) Representative current traces from a cell expressing Kv2.1 channel before (HR; black trace) and during treatment with σ1-R receptor agonist PRE084 (10 μM, red trace). Inset voltage pulse to 50 mV from a holding potential of -60 mV. (B) Representative Kv2.1 channel current traces from a cell treated with σ1-R antagonist BD1047 (50 μM, red trace) compared to total current (black trace). (C) Comparison of Kv2.1 current traces before (HR, black trace) and during treatment with σ1-R antagonist NE100 (50 μM, red trace). (D) Time course of current amplitude at +60 mV. Recordings during Pre84 treatment is represented as red filled circles. (E) Filled circles (red) showing current amplitude time course during treatment of Kv2.1 expressing cells with BD1047. (F) Kv2.1 outward current amplitude as in D in presence of NE100 (50 μM, red filled circles). Both in E and F the solid line represents single exponential curve fit. (G) Average Kv2.1 whole-cell normalized current-voltage plot obtained in control solution (black squares) and during application of Pre084. (H) Comparison of average normalized current-voltage curve in presence of control bath solution and BD1047. (I) Average normalized current-voltage curve determined in control solution (black squares) and NE100 (red circles). (J) The G-V relationships of the control (solid black square), and in presence of BD1047 (blue triangle) or NE100 (red circle) are illustrated. (K) Normalized G-V curves as in J were fitted with the Boltzmann function. Data points in G-K are mean ± SEM (n=5). * P < 0.05 compared to control.

    Article Snippet: We used 1 st order exponential nonlinear curve fitting equation; for the time course data y = A 1 * exp ( − x t 1 ) + y 0 to determine inhibition time constant in Origin (Origin Lab, Northampton, MA).

    Techniques: Expressing, Comparison, Control